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I Tivo’ed Frontline’s “The Medicated Child” recently and finally got around to watching it the other night. This is a follow up from an episode they did on this back in 2001. You can watch and read about it online. It was somewhat disturbing at parts especially when they mentioned a young child who was on several atypical anti-psychotics at the age of four! Here are some of the interesting points brought up:
1. There has been a 4,000% increase in diagnosis of psychiatric problems in young children over the last ten years
2. Although doctors do not agree about bipolar in young children many kids are being diagnosed as being bipolar at ages as young as four years old.
3. There is a growing number of strip mall places offering “brain scans” looking at blood flow to the brain to give a diagnosis. The company featured was co-founded by a social worker and she was the one featured giving the family the diagnosis of the problem. To me this edges on the verge of giving medical advice but not being a medical doctor.
4. In one case they highlighted it was teachers who told the parents their child had ADHD. I know teachers and I do not envy their job but I think suggesting an actual diagnosis is inappropriate.
5. Another big problem mentioned only in passing on the program was that many of these children are being treated by family pediatricians and not by child psychiatrists.
I’m not always a fan of highlighting individual cases which may or may not be typical. However, these do pull on our heart strings and it does highlight how desperate these families become when dealing with “the problem child”. I truly feel for these parents who are trying everything to help their child but nothing seems to work. Just take a look at the discussion page and read what some of these folks have gone through. This situation is what leads to some of these snake oil salesmen mentioned in point 3 above.
Part of the problem is the whole quick fix attitude especially in the US and the resulting expectation (re-inforced by the pharmaceutical industry) that a few pills can solve all your problems. I have always believed that in the case of mental issues that medication and therapy together are much more beneficial than drugs along.
I really liked the program and highly recommend it. You can watch it for free online and they also have lot of information and further interviews with experts here. There is also a Parents Guide.
I personally look forward to the day when we can run a blood test or do a brain scan and come up with a definitive diagnosis and be able to confidently prescribe medications that will solve the problem >90% of the time. Unfortunately, I don’t know if this will occur in my lifetime. This is one situation where I truly hope I am wrong.
Technorati Tags: medicated child
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Since I use Ambien on occasion it was good to hear Dr. Reddy’s Lab is no approved to sell generic Ambien.
Dr. Reddy’s Gets Generic Ambien Approval - Forbes.com:
I was actually behind someone at my local pharmacy recently and they were concerned they thought they had been given the wrong prescription since they did not recognize the name. The pharmacist explained that it was the generic version of Ambien. This could be a big blow to Sanofi-Aventis since they had sales of $1.2 billion in the last year.
While Dr. Reddy’s Lab is the first, there will be several others and the competition will bring down the price. At least 10 other companies have approved generic versions.
Both my wife and I use it on occasion and I love it. I especially use it when traveling to get my body in sync with the local time. I should note that it has recently come under scrutiny and the labeling has been strengthened to warn about possible side effects.
Technorati Tags: Ambien, Sanofi-Aventis, zolpidem tartrate
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Forbes has a report on Novartis purchasing the rights to NicQb, an anti-smoking vaccine from Cytos Biotechnology AG up to $500 million. The initial upfront payment is $29 million.
Novartis Buys Right to Experimental Drug - Forbes.com:
It will be interesting to watch and see how NicQb comes along. Currently it is in phase II studies but if successful could be a huge success. To my knowledge, this is the only vaccine being developed to combat nicotine addition.
Technorati Tags: anti-smoking vaccine, Cytos Biotechnology, NicQb, Novartis
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Since I use Ambien on occasion it was good to hear Dr. Reddy’s Lab is no approved to sell generic Ambien.
Dr. Reddy’s Gets Generic Ambien Approval - Forbes.com:
I was actually behind someone at my local pharmacy recently and they were concerned they thought they had been given the wrong prescription since they did not recognize the name. The pharmacist explained that it was the generic version of Ambien. This could be a big blow to Sanofi-Aventis since they had sales of $1.2 billion in the last year.
While Dr. Reddy’s Lab is the first, there will be several others and the competition will bring down the price. At least 10 other companies have approved generic versions.
Both my wife and I use it on occasion and I love it. I especially use it when traveling to get my body in sync with the local time. I should note that it has recently come under scrutiny and the labeling has been strengthened to warn about possible side effects.
Technorati Tags: Ambien, zolpidem tartrate, Sanofi-Aventis
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I missed posting on this when I first saw it but thought folks might be interested in some new federal guidance for disposing of old or unused prescription medicines.
Proper Disposal of Prescription Drugs
The most important point is that you should NOT flush drugs down the toilet unless the accompanying direction specifically say to do so. Municipal waste water treatment plats are not set up to handle this and it can cause environmental problems. In general, the unused or old medication should be placed in the trash in nondescript containers.
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Forbes recently had an article about a vaccine from GlaxoSmithKline (GSK) that may protect against many strains of bird flu.
Vaccine May Treat Many Bird Flu Strains - Forbes.com:
The vaccine measurably increased the levels of antibodies in 400 adults after they were given two shots. THe levels were high enough to give presumed protection against the strain of bird flu it was designed to work against. The more promising result is that it may protect against other strains. Other companies such as Novartis and Sanofi-Aventis has also seen cross-protection in their vaccines. What is interesting is the GSK is using a proprietary adjunct which can increase the number of doses by 10-fold. This would be vital if there were an epidemic.
Technorati Tags: avian flu, bird flu, GlaxoSmithKline, H5N1, Novartis, Sanofi-Aventis, vaccine
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The AP reports that Indonesia is refusing to share bird flu virus samples with the World Health Organization (WHO) unless they sign an agreement saying it WILL NOT be used to develop an “expensive vaccine”.
While I understand that Indonesia does not want to have pay high prices for a vaccine that may be developed in the future, this seems short sighted. Indonesia is not the only source of the samples and if a major pharma companies wants to get samples, I’m am sure there are other options and other countries. The only reason Indonesia is important is because they seem to have more cases and those cases need to be tracked to determine how the virus may be mutating.
This is a major change from previous understandings where nations share information for public health purposes. One of the reasons WHO has an interest there is Indonesia is a likely center for any future pandemic since it is heavily populated and many people live in close proximity to birds. THis refusal to share seems to put the Indonesian people at even more risk if something should occur.
Technorati Tags: avian flu, bird flu, Indonesia, WHO
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This article occurred over a month ago but I hadn’t gotten around to commenting on it yet.
State OKs Plan Against E. Coli Outbreaks - Forbes.com:
Seems California as instituting a voluntary program for produce shippers and handlers where they agree to only work with other companies who are taking preventative steps to stop e. coli and other contamination. Among the proposals are fencing fields to prevent ingress of wildlife and routine testing of irrigation water for bacteria.
I think these are good ideas but it will be interesting to see how successful it is.
Technorati Tags: e coli, food safety
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Here are some article regarding flu pandemics in general and some on the bird flu that have come across my desk recently.
H5N1 bird flu outbreak confirmed on English farm - health - 03 February 2007
About a month ago there was an outbreak of Bird flu on a turkey farm in England. The interesting thing in this article is the timing of the outbreak. It occurred when birds are not migrating and so it was not immediately obvious how this started.
New ScientistPandemic flu may be only two mutations away - health - 01 February 2007 - New Scientist
Interesting article concerning work on how much change needs to occur for H5N1 to have the potential for creating a pandemic. The researchers compared the 1918 flu with the H5N1 bird flu and determined it may only take changes at two amino acids. Unfortunately, they don’t comment on the probabilities of each of these happening and I would note that you have to multiply the percentages to arrive at an overall probability. If one has a probability of 10% and the second also is 10% then the overall probability (assuming both are necessary) is 1%.
World moves closer to having bird flu vaccine: WHO | Top News | Reuters.com
Article about developing a vaccine for bird flu. Mentions CSL Ltd in Australia has developed a vaccine that brins about a strong immune response. Also mentions the GlaxoSmithKline is working on this as well as
The above article concerns Baxter having an agreement with Indonesia and that the Indonesia is no longer sharing samples. They are interested in the IP rights surrounding the H5N1 strain.
An article further clarifying the situation with regard to sharing samples of bird flu from humans.
Flu Preparedness Still Lags Globally - Forbes.com
Report about the World Health Organization report that the world as a whole is poorly prepared for dealing with any sort of word-wide flu pandemic.
Technorati Tags: bird flu, flu, flu pandemic, flu vaccine
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There have been many reports today, most saying basically the same thing, Here are two that cover the issue.
Report: FDA Eyes Kids’ Cold Drugs - Forbes.com
Warnings sought on kids’ cold medicine - Yahoo! News
The cause of this was a filing by Baltimore health authorities and others yesterday (Mar 1, 2007). A recent report from the Center for Disease Control that noted 1,500 toddlers and babies had been taken to the emergency room because of over the counter cough and cold remedies over a two year period. And the medical examiner in Baltimore noted that at least four children under the age of four have had their deaths linked to these products over a five year period.
None of these products are recommended for children younger than two and all state that it should not be used except under the advice of your doctor. But the report says that many products contain the name “infant” or “baby” such as “baby aspirin”. These along with pictures of mothers holding infants and other children much younger than two are shown in the packaging.
I personally think the warnings are adequate but that some of the pictures and wordings in the packaging should be changed so as to not be misleading. I’d like to see the OTC industry do this voluntarily but I don’t think that will happen. And I don’t think the FDA is likely to step in and require that. It is much more likely in my opinion for the FDA to issue a statement saying that these products should not be used in children younger than two without instruction from their doctor.
This does bring up the bigger issue of how do you determining the proper dosing of these OTC products in children? Most data is from extrapolation of adult data and may not be appropriate to children. THis is really the bigger question and one for which there is no answer currently.
Technorati Tags: drug safety, pediatric drugs
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