Resveratrol in Wine Keeps Fat Mice Healthy
I recent report from the Harvard Medical School and the National Institute on Aging shows that resveratrol found in red wine can keep fat mice healthy.
Wine extract keeps fat mice healthy - Yahoo! News
Resveratrol is chemically known as 5-[(E)-2-(4-hydroxyphenyl)-ethenyl]benzene-1,3-diol [501-36-0] and the structure is shown below.
It is found mainly in the skins of red grapes as well as peanuts and berries such as blueberries, and cranberries.
The report states that although the mice are fat, their internal organs looked fine and they did not appear to suffer abnormal effects normally associated with obesity. death was down 31% from a control group. It is way too early though to make any conclusions for humans and the does to see this effect were quite high. A person would have to drink ~100 bottles of red wine per day to get the levels of resveratrol they used in these animal studies.. At least Sirtris Pharmaceuticals will be doing trials and intend to file a drug application through the FDA.
It should be pointed out that resveratol is also sold as a non-regulated supplements but that little safety studies have been performed on it to date.
Other Resources
• Therapeutic potential of resveratrol: the in vivo evidence : Nature Reviews Drug Discovery
• A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts
• Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells
• resveratrol information from Linus Pauling Institute at Oregon State University (great source of information)
• resveratrol - Yahoo! Search Results
• resveratrol - Google Search
• Resveratrol (from quackwatch.org; lots of references)
• Resveratrol - Wikipedia, the free encyclopedia
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