QDIS Blog

A blog about chemistry, drug development, science, and technology

October 12, 2006

New Drug Effective Against Bird Flu

by @ 8:18 am.  Filed under Science

Drug researcher reports that a new peptide fragment shows activity against influenza A including the H5N1 avian flu in vitro. The fragment is only 20 amino acid residues

New drug provides effective defence against bird flu

The above headline is misleading since the work has only been done in vitro and not in patients. I don’t have access to the actual article so I can’t comment on the amino acid sequence.

The peptide seems to prevent viruses from entering the cell and the survival rate for the animal models was 100%. While this is promising, there have been many cases of drugs showing excellent activity in animal models but never working in humans. It will be interesting to see if this develops and goes beyond the preclinical stage. Since this work comes from the University of Wisconsin-Madison, it would take a deal with a pharmaceutical or biotech company before it moves to the next stage.

Sources

Abstract: INHIBITION OF INFLUENZA VIRUS INFECTION BY A NOVEL ANTIVIRAL PEPTIDE THAT TARGETS VIRAL ATTACHMENT TO CELLS — Jones et al., — The Journal of Virology

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