A blog about chemistry, drug development, science, and technology
Since I personally suffer severely from post-operative vomiting and nausea I was especially interested in Merck’s new approval for Emend. This is the first new treatment for this in over 10 years.
Merck Gets Added FDA OK for Emend: Financial News - Yahoo! Finance
I have only had surgery twice; once for a knee injury and the second for a deviated septum in my nose. Both times, I was very sick afterwards and could not keep down even water for about 48 hours. I was told the first time it was due to some carrier gases they used in the anesthesia (this was back in 1978) and more recently after the nose surgery it was said to be due to the fentanyl pain reliever. It’s nice to know this and I’ll certainly keep it in mind if I ever have to have electively surgery again.
I should mention that this is also used for nausea caused by chemotherapy.
Here’s some more information on Emend.
EMEND* (aprepitant) is a substance P/neurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one.
Its empirical formula is C23H21F7N4O3, and its structural formula is:

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