QDIS Blog

Just wanted to let folks know I’ve created some TagClouds of web feeds (RSS feeds) relate to chemistry and posted them. Each TagCloud has a list of the feeds it looks through to generate the keywords. The size of the word is in relation to how many times it occurs. Clicking on any of these words will give you other items in that set of feeds containing that term. Then you can click on a given entry and that item. If you want, you can use the “Y! Search Related Terms ” button to see related results from a Y!Q search. This doesn’t work so well for the chemistry articles but works great for the news and blog TagClouds.

I’ve set up TagCloud for the following:

• American Chemical Society (ACS) organic journals
• Royal Society of Chemistry (RSC) organic journals
• all ACS journals
• all RSC journals
• pharmaceutical news
• interesting science blogs that I read

Let me know what you think.

Technorati Tags: tagcloud

Email Ed Vawter

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Amino Alcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids
J. Am. Chem. Soc., 128 (16), 5360 -5361, 2006. 10.1021/ja0613761 S0002-7863(06)01376-X
Web Release Date: April 1, 2006

Gegory Fu and his group at MIT continue to make progress in the metal catalyzed coupling of unactivated halides with boron reagents. In this case, primary and secondary chlorides can be made to react with arylboronic acids in good yields (66-92%) using 1,2-amino alcohols instead of the more typical bipyridine ligands. The best performing amino alcohol in this article is prolinol. One of the key advantages of this system is that the reagents are air-stable (NiCl2-Glyme) and readily available. Since a wide variety of amino alcohols are known, it will be interesting to see what others will be reported to work in the future.

Technorati Tags: nickle catalyst, Suzuki reaction

Email Ed Vawter

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